Development of the liposome encapsulated stroma free hemoglobin (SFH) from out dated human red blood cells as the blood substitute.
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چکیده
منابع مشابه
Numerical study on flows of red blood cells with liposome-encapsulated hemoglobin at microvascular bifurcation.
Flow analysis at microvascular bifurcation after partial replacement of red blood cell (RBC) with liposome-encapsulated hemoglobin (LEH) was performed using the lattice Boltzmann method. A two-dimensional symmetric Y bifurcation model with a parent vessel diameter of 20 mum and daughter branch diameters of 20 microm was considered, and the distributions of the RBC, LEH, and oxygen fluxes were c...
متن کاملPolyethylene glycol-modified liposome-encapsulated hemoglobin: a long circulating red cell substitute.
A major obstacle in the development of red cell substitutes has been overcoming their short circulation persistence. In this study, distearoyl phosphoethanolamine polyethylene glycol 5000 (PEG-PE) (10 mol%) was added to the formulation of liposome-encapsulated hemoglobin (LEH) to decrease reticuloendothelial system uptake and prolong LEH circulation persistence. PEG-LEH was radiolabeled with te...
متن کاملIn vivo biodistribution of a radiolabeled blood substitute: 99mTc-labeled liposome-encapsulated hemoglobin in an anesthetized rabbit.
Liposome-encapsulated hemoglobin (LEH) is an erythrocyte substitute that is a potential resuscitative fluid for the in vivo delivery of oxygen. We have noninvasively imaged radiolabeled LEH in vivo with technetium-99m (99mTc) to study the biodistribution in an anesthetized rabbit. Rabbits (2.5 kg, n = 8) were infused with 30 ml of LEH (200 mg of phospholipid, 2.5 g of hemoglobin per kg of body ...
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In a recent review of the literature (1,2), many of the problems dealing with cellular agglutination caused by ricin are presented and discussed. Although this phenomenon was first described in 1888 by Stilhnark, reactions involved in the agglutination of cells are poorly understood. The present report is concerned with factors which affect agglutination. Data are presented which show that eryt...
متن کاملSafety Evaluation of Hemoglobin-Albumin Cluster “HemoAct” as a Red Blood Cell Substitute
A hemoglobin (Hb) wrapped covalently by human serum albumins (HSAs), a core-shell structured hemoglobin-albumin cluster designated as "HemoAct", is an O2-carrier designed for use as a red blood cell (RBC) substitute. This report describes the blood compatibility, hemodynamic response, and pharmacokinetic properties of HemoAct, and then explains its preclinical safety. Viscosity and blood cell c...
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ژورنال
عنوان ژورنال: membrane
سال: 1995
ISSN: 0385-1036,1884-6440
DOI: 10.5360/membrane.20.282